Picture of Oehler
Associate Member
Fred Hutchinson Cancer Research Center
Associate Professor of Medicine
Division of Hematology
University of Washington School of Medicine

Faculty Information

Biography

Dr. Oehler's research delves into the tyrosine kinase inhibitor imatinib mesylate (Gleevec), and now the second generation tyrosine kinase inhibitors dasatinib and nilotinib, which have dramatically altered treatment strategies in chronic myeloid leukemia (CML).  Outcomes for early (or chronic phase) disease are excellent.  However, a significant minority of chronic phase CML patients and many advanced CML patients develop resistance to therapy.  In the laboratory we are examining mechanisms involved in CML disease progression and the effects of tyrosine kinase inhibitor therapy on the underlying natural history of CML disease.  In the clinic we are pursuing phase one studies of new agents in the treatment of CML and AML.

CML provides a unique disease model in which to apply a translational approach.  Using microarray-based gene and microRNA expression studies of a large group of CML patients, we have identified expression changes in patients that are highly associated with disease progression and therapy resistance.   We are using these data to investigate several questions including:  can we identify candidates that predict which patients are at risk for early therapy failure or disease progression and can we determine how these genes and their targets cause disease progression and therapy resistance?  To answer the first question we are investigating a group of prognostic markers at diagnosis that can identify patients at risk for early disease progression or therapy failure.  Expression of these diagnostic mar
 

Education & Training: 
B.A.
Harvard University
Cambridge, MA
1985-1989
Post-baccalaureate premed courses
S.U.N.Y
New York
1990-1992
M.D.
Case Western Reserve University School of Medicine
Clevland, OH
1993-1997
Internship, Internal Medicine
University of Washington Affiliated Hosptials
Seattle, WA
1997-1998
Residency, Internal Medicine
University of Washington Affiliated Hospitals
Seattle, WA
1998-2000
Hematology Fellowship
University of Washington Affiliated Hospitals
Seattle, WA
2000-2004
Post-Doctoral Research Fellow
Jerald Radich Laboratory, FHCRC
Seattle, WA
2002-2004