My clinical research focuses on chronic complications of sickle cell disease in adults, with a specific interest in osteonecrosis, a prevalent cause of skeletal morbidity associated with chronic sickle cell pain, opioid analgesics overuse and high rates of acute care utilization. Current management with physical therapy, analgesics and joint replacement surgery fail to address the underlying pathophysiology, predictive biomarkers or prognostic factors of sickle cell-related osteonecrosis. My long-term goals are to develop safe and effective non-surgical interventions to alleviate symptoms, retard progression and improve health-related outcomes for the 20-30% of people with sickle cell disease affected by osteonecrosis.
825 Eastlake Ave E.MS CE3-300Seattle, WA 98109
skeletal disorders (e.g., osteonecrosis, impaired bone accrual, accelerated bone deficits, etc.,) in sickle cell disease
sickle cell disease, anemia, thrombocytopenia, leukopenia, myeloproliferative disorders, myelodysplastic syndrome, transfusional iron overload, thrombosis, coagulopathy, etc,.