Our research group is interested in how biomolecules and cells sense and respond to force, and how these mechano-responses contribute to physiology and disease mechanisms. We combine single-molecule fluorescence imaging and force manipulation methods, microfluidics, and stem cell biology to understand the molecular mechanisms governing physiological functions and seek new methodologies for therapeutics testing and treatment of disease. Our current research focuses on mechanosensor proteins related to blood and circulatory system disorders.
Please visit the lab website for more information.
University of Washington
850 Republican St. S576
Seattle, WA 98109
Biophysics of cellular mechanosensation (how cells sense and respond to force)
Molecular mechanisms of bleeding disorders and thrombosis, such as von Willebrand disease
Vascular disease modeling using iPS cells, gene editing, and organoids