Bonig_Halvard
Affiliate Professor, Division of Hematology
University of Washington
Professor for Translational Development of Cellular Therapeutics, Institute for Transfusion Medicine and Immunotherapy
Goethe University Medical School

Faculty Information

Biography

Dr. Bönig is pursuing two largely independent research programs, one applied and one basic. 

Clinical/applied: His Cell Therapy Group is developing GMP- and EP-compatible, fully regulator-approved processes for manufacturing and testing of cell-based therapeutics, including Advanced Therapy Medicinal Products (ATMPs). The GMP-facility, after formal process and assay validation and regulatory approval, generates clinical trial specimen and routine clinical cell therapy products predominantly for immunotherapy and regenerative medicine. Besides technology development, T-cell based therapeutics, both primary and engineered, have been a major focus. The Department maintains partnerships with academic and commercial entities invested in cellular therapy. He is also interested in cell donor safety and ethics.

Basic research: The Hematopoietic Stem Cell Research Group is investigating stem cell-niche interactions, specifically in the context of stem cell mobilization/stem cell maintenance and disruption of leukemia stem cell-niche interactions with a view to leukemia cell eradication. Aberrant CXCR4 signaling in the context of normal and malignant hematopoiesis remains a research focus. Recent advances include pre-clinical and clinical development of a novel, highly potent CXCR4 antagonist (POL6326) and the discovery of an endogenous CXCR4 antagonist (EPI-X4) which is cleaved, in an acidic milieu, off of albumin and according to preliminary data contributes to the integrity of the mucosal barrier.

Education & Training: 
Degree of Magister Artium (M.A.) in English Literature, Old English, and Art History
Heinrich-Heine-University Dusseldorf
Dusseldorf, Germany
1989-1995
MD
Henrich-Heine University Dusseldorf, St. Bartholomew's Hospital Medical School, and the University of Tennessee
Dusseldorf, Germany; London, England; and Memphis, TN
1989-1996
Residency in Pediatrics
Henrich-Heine University Center of Child Health
Dusseldorf, Germany
1997-2002
Transfusion Medicine
German Red Cross Blood Service BaWuHe
Frankfurt, Germany
Contact
Phone: 
+49-69-6782177
Mailing Address: 

Institute for Transfusion Medicine and Immunohematology

Goethe University Medical School Sandhofstr.

1, 60528 Frankfurt, Germany

Research & Clinical Interests
Research Interests: 

Interactions of normal or malignant stem cells with the bone marrow niche, stem cell mobilization, stem cell expansion.

Clinical Interests: 

Translational cell therapy, specifically cellular immunotherapy. Stem cell mobilization.

Publications