Bonig_Halvard
Affiliate Professor of Hematology
University of Washington School of Medicine
Professor for Translational Development of Cellular Therapeutics (GMP), Institute for Transfusion Medicine and Immunotherapy
Department of Cellular Therapeutics/Cell Processing (GMP), Goethe University Medical School

Faculty Information

Biography

Dr. Bönig is pursuing two largely independent research programs, one applied and one basic. 

Clinical/applied: His Cell Therapy Group is developing GMP- and EP-compatible, fully regulator-approved processes for manufacturing and testing of cell-based therapeutics, including Advanced Therapy Medicinal Products (ATMPs). The GMP-facility, after formal process and assay validation and regulatory approval, generates clinical trial specimen and routine clinical cell therapy products predominantly for immunotherapy and regenerative medicine. Besides technology development, T-cell based therapeutics, both primary and engineered, have been a major focus. The Department maintains partnerships with academic and commercial entities invested in cellular therapy. He is also interested in cell donor safety and ethics.

Basic research: The Hematopoietic Stem Cell Research Group is investigating stem cell-niche interactions, specifically in the context of stem cell mobilization/stem cell maintenance and disruption of leukemia stem cell-niche interactions with a view to leukemia cell eradication. Aberrant CXCR4 signaling in the context of normal and malignant hematopoiesis remains a research focus. Recent advances include pre-clinical and clinical development of a novel, highly potent CXCR4 antagonist (POL6326) and the discovery of an endogenous CXCR4 antagonist (EPI-X4) which is cleaved, in an acidic milieu, off of albumin and according to preliminary data contributes to the integrity of the mucosal barrier.

Education & Training: 
Degree of Magister Artium (M.A.) in English Literature, Old English, and Art History
Heinrich-Heine-University Dusseldorf
Dusseldorf, Germany
1989-1995
MD
Henrich-Heine University Dusseldorf, St. Bartholomew's Hospital Medical School, and the University of Tennessee
Dusseldorf, Germany; London, England; and Memphis, TN
1989-1996
Residency in Pediatrics
Henrich-Heine University Center of Child Health
Dusseldorf, Germany
1997-2002
Transfusion Medicine
German Red Cross Blood Service BaWuHe
Frankfurt, Germany